Fatal lactic acidosis from imported phenformin--report of two cases

Singapore Med J. 1996 Oct;37(5):482-4.

Abstract

This report describes two diabetic patients who presented with severe lactic acidosis. Both patients had been taking a medicine (phenformin) which they had obtained from China, and which has been withdrawn from Singapore since 1977. Both cases were admitted with severe metabolic acidosis and were treated with intravenous sodium bicarbonate and intensive care support with unsuccessful outcomes.

Publication types

  • Case Reports

MeSH terms

  • Acidosis, Lactic / etiology*
  • Acidosis, Lactic / therapy
  • Aged
  • China
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Fatal Outcome
  • Humans
  • Hypoglycemic Agents / adverse effects*
  • Hypoglycemic Agents / therapeutic use
  • Male
  • Phenformin / adverse effects*
  • Phenformin / therapeutic use
  • Singapore

Substances

  • Hypoglycemic Agents
  • Phenformin