Synthesis and antitumor activity of spin labeled derivatives of podophyllotoxin

Life Sci. 1997;60(8):511-7. doi: 10.1016/s0024-3205(96)00689-3.

Abstract

Three new nitroxyl labeled derivatives of podophyllotoxin 4-6 have been synthesized and evaluated for their antitumor activity in vitro. Compounds 4-6 showed significant inhibitory activity against human nasopharyngeal carcinoma KB,lung cancer A549 and stomach carcinoma SGC-7901 cells, as well as mouse leukemia L1210 and P388 cells. Compounds 4 and 5 exhibited comparable or superior activity to clinically used etoposide (VP-16,2) in their inhibition of these cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemical synthesis*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Podophyllotoxin / chemical synthesis*
  • Podophyllotoxin / chemistry
  • Podophyllotoxin / pharmacology*
  • Spectrophotometry, Infrared
  • Spin Labels
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Spin Labels
  • Podophyllotoxin