Respective role of TNF receptors in the development of experimental cerebral malaria

J Neuroimmunol. 1997 Feb;72(2):143-8. doi: 10.1016/s0165-5728(96)00185-3.

Abstract

The respective role of the two receptors of TNF in experimental cerebral malaria (CM) was investigated. During CM, a significant upregulation of TNF-receptor 2 (TNFR2), but not of TNFR1, was found in brain microvessels of susceptible, but not resistant mice. Mice genetically deficient for TNFR2 (Tnfr2null) were significantly protected from CM, while TNFR1-deficient (Tfnr1null) mice were as susceptible as wild-type mice. The protection of Tnfr2null mice could be explained by their absence of ICAM-1 upregulation and leukocyte sequestration, known to occur in brain microvessels of CM-susceptible animals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / blood supply
  • Brain / immunology
  • Brain / metabolism
  • Disease Models, Animal
  • Disease Susceptibility
  • Malaria, Cerebral / etiology*
  • Malaria, Cerebral / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred CBA
  • Microcirculation / immunology
  • Microcirculation / metabolism
  • Plasmodium falciparum
  • Receptors, Tumor Necrosis Factor / physiology*
  • Up-Regulation / immunology

Substances

  • Receptors, Tumor Necrosis Factor