TMC-1 A, B, C and D, new antibiotics of the manumycin group produced by Streptomyces sp. Taxonomy, production, isolation, physico-chemical properties, structure elucidation and biological properties

J Antibiot (Tokyo). 1996 Dec;49(12):1212-20. doi: 10.7164/antibiotics.49.1212.

Abstract

Four new antitumor antibiotics, TMC-1 A, B, C and D were isolated from a fermentation broth of Streptomyces sp. A-230. Spectroscopic studies have shown that TMC-1 A to D were new members of the manumycin class of antibiotics. These antibiotics showed cytotoxic activities against various tumor cell lines in vitro.

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / biosynthesis
  • Antibiotics, Antineoplastic / chemistry*
  • Antibiotics, Antineoplastic / isolation & purification
  • Antibiotics, Antineoplastic / pharmacology*
  • Culture Media
  • Cyclohexanones / chemistry
  • Cyclohexanones / isolation & purification
  • Cyclohexanones / metabolism
  • Cyclohexanones / pharmacology
  • Drug Screening Assays, Antitumor
  • Fermentation
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Molecular Structure
  • Polyenes / chemistry
  • Polyenes / isolation & purification
  • Polyenes / metabolism
  • Polyenes / pharmacology
  • Polyunsaturated Alkamides
  • Streptomyces / classification
  • Streptomyces / isolation & purification
  • Streptomyces / metabolism*
  • Tumor Cells, Cultured

Substances

  • Antibiotics, Antineoplastic
  • Culture Media
  • Cyclohexanones
  • Polyenes
  • Polyunsaturated Alkamides
  • TMC 1 A
  • TMC 1 B
  • TMC 1 C
  • TMC 1 D
  • manumycin