Abstract
Investigators from Belarus Center for bone marrow transplantation examined the efficacy of preventing hemorrhagic cystitis induced by high-dose cyclophosphamide in preparation for hemopoiesis precursor transplantation in 22 patients with hematological diseases. The proposed preventive method implied administration of mesna (2-merkaptoetan-sulphonate) and alkaline forced diuresis. Its effectiveness was found high.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adolescent
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Adult
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Bone Marrow Transplantation / adverse effects*
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Child
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Combined Modality Therapy
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / adverse effects
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Cystitis / etiology
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Cystitis / prevention & control*
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Diuresis / drug effects
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Female
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Hematologic Neoplasms / complications
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Hematologic Neoplasms / therapy*
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Hematopoietic Stem Cell Transplantation / adverse effects*
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Hemorrhage / etiology
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Hemorrhage / prevention & control*
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Humans
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Male
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Mesna / administration & dosage