Modelling of the brain ischemic hypoxia, the hypophysis including, by ligation of the left internal carotid artery in dogs results in weight enlargement of the hypophysis, marked edema of the parenchyma, discomplexity of the cellular elements of the anterior pituitary lobe with morphological signs of hypofunctional condition of the increting cells in the organ studied. Ischemic hypoxia produces lumen augmentation of blood vessels in some areas of the anterior pituitary lobe with resulting increased circulatory capacity in the anterior pituitary lobe. Comparing with the data available in the literature, we conclude that blood circulation manifests a nonspecific reaction to different hypoxic models, while cellular reaction is more specific.