Abstract
The rootwood of Aeschynomene mimosifolia Vatke (Leguminosae) has yielded a new neoflavonoid, mimosifoliol (1), and an unusual C16-styrylcycloheptenone derivative, mimosifolenone (2). The structures of these compounds were determined on the basis of spectral analysis. Compound 1 demonstrated weak activity in DNA-strand scission assay, while compound 2 was found to be inactive. Mimosifoliol (1) was inactive toward several human cell lines, while 2 was moderately active against the KB cell line.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acrylates / isolation & purification*
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Acrylates / pharmacology
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cycloheptanes / isolation & purification*
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Cycloheptanes / pharmacology
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DNA Damage
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Drug Screening Assays, Antitumor
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Guaiacol / analogs & derivatives*
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Guaiacol / isolation & purification
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Guaiacol / pharmacology
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Humans
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KB Cells
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Plant Extracts / chemistry
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Plant Roots / chemistry*
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Plants, Medicinal / chemistry*
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Styrenes / isolation & purification*
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Styrenes / pharmacology
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Tumor Cells, Cultured
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Zimbabwe
Substances
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Acrylates
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Antineoplastic Agents, Phytogenic
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Cycloheptanes
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Plant Extracts
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Styrenes
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mimosifolenone
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mimosifoliol
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Guaiacol