Abstract
It was shown that L-arginine (up to 0.5 mM) competitively inhibits the NADPH-diaphorase activity in drosophila melanogaster. The value of inhibition constant is equal to 103 microM. In the presence of higher concentration of L-arginine total NADPH-diaphorase activity includes not only the L-arginine inhibited component, but also the non-inhibited one.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arginine / pharmacology*
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Binding, Competitive / drug effects
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Dose-Response Relationship, Drug
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Drosophila melanogaster / drug effects*
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Drosophila melanogaster / enzymology
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NADPH Dehydrogenase / antagonists & inhibitors
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NADPH Dehydrogenase / drug effects*
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NADPH Dehydrogenase / metabolism
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Nitric Oxide Synthase / drug effects
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Nitric Oxide Synthase / metabolism
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Substrate Specificity / drug effects
Substances
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Arginine
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Nitric Oxide Synthase
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NADPH Dehydrogenase