Biochemical mass spectrometry: worth the weight?

Chem Biol. 1996 Sep;3(9):707-15. doi: 10.1016/s1074-5521(96)90245-8.

Abstract

The utility of mass spectrometry for the analysis of biological molecules has been enhanced by the development of two techniques that generate gas-phase ions via nondestructive vaporization and ionization. These techniques can be used not only to determine the primary structure of biological molecules with unprecedented accuracy, but also to map noncovalent biomolecular interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Angiotensin I / chemistry
  • DNA / analysis
  • DNA / chemistry
  • Isomerases / chemistry
  • Mass Spectrometry / instrumentation
  • Mass Spectrometry / methods*
  • Molecular Weight
  • Oligosaccharides / analysis
  • Oligosaccharides / chemistry
  • Peptides / analysis
  • Peptides / chemistry
  • Peptides / metabolism
  • Proteins / analysis
  • Proteins / chemistry
  • Proteins / metabolism
  • Trypsin / metabolism

Substances

  • Oligosaccharides
  • Peptides
  • Proteins
  • DNA
  • Angiotensin I
  • Trypsin
  • 4-oxalocrotonate tautomerase
  • Isomerases