Abstract
Cancers producing colony-stimulating factors and associated with marked leukocytosis are relatively rare. We report here a case of a thyroid cancer producing both granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). A 72-year-old woman had a thyroid carcinoma with significant neutrophilia and eosinophilia without any evidence of infection. The serum concentrations of both G-CSF and GM-CSF were elevated significantly in this patient, which might have induced the leukocytosis. Furthermore, the G-CSF concentrations in thyroid tumor tissue and metastatic lesions in the lung and skin examined at autopsy also were extremely high.
MeSH terms
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Aged
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Biomarkers, Tumor
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Biopsy
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Carcinoma / complications
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Carcinoma / diagnosis
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Carcinoma / metabolism*
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Colony-Stimulating Factors / biosynthesis*
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Eosinophilia / blood
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Eosinophilia / complications*
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Eosinophilia / diagnosis
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Fatal Outcome
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Female
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Granulocyte Colony-Stimulating Factor / biosynthesis
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Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis
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Humans
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Leukocytosis / blood
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Leukocytosis / complications*
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Leukocytosis / diagnosis
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Neutrophils
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Thyroid Neoplasms / complications
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Thyroid Neoplasms / diagnosis
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Thyroid Neoplasms / metabolism*
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Tomography, X-Ray Computed
Substances
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Biomarkers, Tumor
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Colony-Stimulating Factors
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Granulocyte Colony-Stimulating Factor
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Granulocyte-Macrophage Colony-Stimulating Factor