The production of colony-stimulating factors by thyroid carcinoma is associated with marked neutrophilia and eosinophilia

Intern Med. 1996 Oct;35(10):815-20. doi: 10.2169/internalmedicine.35.815.

Abstract

Cancers producing colony-stimulating factors and associated with marked leukocytosis are relatively rare. We report here a case of a thyroid cancer producing both granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). A 72-year-old woman had a thyroid carcinoma with significant neutrophilia and eosinophilia without any evidence of infection. The serum concentrations of both G-CSF and GM-CSF were elevated significantly in this patient, which might have induced the leukocytosis. Furthermore, the G-CSF concentrations in thyroid tumor tissue and metastatic lesions in the lung and skin examined at autopsy also were extremely high.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biomarkers, Tumor
  • Biopsy
  • Carcinoma / complications
  • Carcinoma / diagnosis
  • Carcinoma / metabolism*
  • Colony-Stimulating Factors / biosynthesis*
  • Eosinophilia / blood
  • Eosinophilia / complications*
  • Eosinophilia / diagnosis
  • Fatal Outcome
  • Female
  • Granulocyte Colony-Stimulating Factor / biosynthesis
  • Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis
  • Humans
  • Leukocytosis / blood
  • Leukocytosis / complications*
  • Leukocytosis / diagnosis
  • Neutrophils
  • Thyroid Neoplasms / complications
  • Thyroid Neoplasms / diagnosis
  • Thyroid Neoplasms / metabolism*
  • Tomography, X-Ray Computed

Substances

  • Biomarkers, Tumor
  • Colony-Stimulating Factors
  • Granulocyte Colony-Stimulating Factor
  • Granulocyte-Macrophage Colony-Stimulating Factor