[The predictive value of cyclic nucleotide ratio in the prognosis of experimental tumors]

Vopr Onkol. 1996;42(4):45-8.
[Article in Russian]

Abstract

The report deals with the predictive value of a procedure for lifetime detection of tumor in experimental animals. The database included the results of regular cAMP/cHMP tests carried out in 54 rats with radionuclide-inducted tumors and 24 tumor-free rats. The data were processes by statistical methods and the informative value was determined on the basis of standard recommendations. The test was shown to have high sensitivity (85.2%), sufficient predictive value (73%) and diagnostic effectiveness (68%). Application of the test in groups of humans at high risk of tumor development is discussed.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Cyclic AMP / analysis
  • Cyclic GMP / analysis
  • Neoplasms, Experimental / etiology
  • Neoplasms, Experimental / genetics*
  • Nucleotides, Cyclic / analysis*
  • Predictive Value of Tests
  • Prognosis
  • Rats
  • Sensitivity and Specificity

Substances

  • Nucleotides, Cyclic
  • Cyclic AMP
  • Cyclic GMP