Application of the modified relative dose response test to pregnant Indonesian women for assessing vitamin A status

Eur J Clin Nutr. 1995 Dec;49(12):897-903.

Abstract

Objective: To determine the prevalence of subclinical vitamin A deficiency (vitamin A inadequacy) in Indonesian pregnant women as assessed by the modified relative dose response test.

Design: Cross-sectional study of the vitamin A statuses of pregnant (second trimester) women randomly selected from ten different villages.

Setting: West Java, Indonesia.

Subjects: A group of 144 pregnant women recruited from the local health posts.

Interventions: Modified relative dose response (MRDR) test, serum retinol determination and gynecological examinations.

Results: The mean (s.d.) MRDR ratio was 0.039 +/- 0.031. Of the women tested, the vitamin A status of 17% was provisionally classified as being marginal (subclinically deficient) (MRDR ratio > or = 0.060), of 35% as being uncertain (MRDR ratio between 0.030 and 0.060) and of 48% as being satisfactory (MRDR ratio < or = 0.030).

Conclusion: If the vitamin A statuses of the 'uncertain' group are also deemed to be unsatisfactory, approximately half of the pregnant Indonesian women tested could benefit from an increased intake of vitamin A.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Cross-Sectional Studies
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Indonesia / epidemiology
  • Nutrition Surveys
  • Nutritional Status*
  • Pregnancy
  • Pregnancy Complications / blood*
  • Pregnancy Complications / epidemiology
  • Prevalence
  • Tretinoin / analogs & derivatives*
  • Vitamin A / blood*
  • Vitamin A Deficiency / blood*
  • Vitamin A Deficiency / epidemiology

Substances

  • Vitamin A
  • 3,4-didehydroretinoic acid
  • Tretinoin