Scleroderma-polymyositis overlap syndrome associated with anti-Ku antibody and rimmed vacuole formation

J Rheumatol. 1996 Nov;23(11):1991-4.

Abstract

Scleroderma-polymyositis overlap syndrome is strongly associated with certain autoantibodies, such as anti-PM-Scl antibody and anti-Ku antibody. We describe a case of scleroderma-polymyositis overlap syndrome associated with anti-Ku antibody, which revealed rimmed vacuole formation in addition to intranuclear and intracytoplasmic filamentous inclusions in muscle biopsy specimens.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, Nuclear*
  • Autoantibodies / immunology*
  • Biopsy
  • Cell Nucleus / ultrastructure
  • Cytoplasm / ultrastructure
  • DNA Helicases*
  • DNA-Binding Proteins / immunology*
  • Female
  • Humans
  • Inclusion Bodies / ultrastructure
  • Ku Autoantigen
  • Microscopy, Electron
  • Muscle, Skeletal / ultrastructure*
  • Nuclear Proteins / immunology*
  • Polymyositis / complications
  • Polymyositis / etiology*
  • Scleroderma, Systemic / complications
  • Scleroderma, Systemic / etiology*
  • Syndrome
  • Vacuoles / ultrastructure*

Substances

  • Antigens, Nuclear
  • Autoantibodies
  • DNA-Binding Proteins
  • Nuclear Proteins
  • DNA Helicases
  • XRCC5 protein, human
  • Xrcc6 protein, human
  • Ku Autoantigen