Pharmacological and histopathological aspects of 1-methyl-4-phenyl-4-hydroxy-piperidine (MPIP)

S Bruno; N DeLaurentis; M A Milillo; G Tantillo; A Perillo

Pharmacological and histopathological aspects of 1-methyl-4-phenyl-4-hydroxy-piperidine (MPIP)

Boll Chim Farm. 1996 Apr;135(4):236-8.

Authors

S Bruno¹, N DeLaurentis, M A Milillo, G Tantillo, A Perillo

Affiliation

¹ Dipartimento Farmaco Chimico--Facoltà di Farmacia di Bari, Italy.

PMID: 8913053

Abstract

Increasing dosages of 1-methyl-4-phenyl-4-hydroxypiperidine (MPIP) were administered i.p. to rats. Histopathological examination of these animals revealed effects on the central nervous system.

MeSH terms

Animals
Behavior, Animal / drug effects
Brain / pathology
Central Nervous System Agents / chemical synthesis*
Central Nervous System Agents / pharmacology
Central Nervous System Agents / toxicity
Male
Piperidines / chemical synthesis*
Piperidines / pharmacology
Piperidines / toxicity
Rats

Substances

1-methyl-4-phenyl-4-hydroxypiperidine
Central Nervous System Agents
Piperidines