PRAD1/Cyclin D1 gene overexpression in mantle cell lymphoma

Leuk Lymphoma. 1996 Mar;21(1-2):37-42. doi: 10.3109/10428199609067577.

Abstract

The t(11;14) (q13;q32) translocation and its molecular counterpart Bcl-1 rearrangement are consistent features of mantle cell lymphoma (MCL). This translocation activates the PRAD1/cyclin D1 gene that is considered to be the Bcl-1 oncogene. PRAD1/cyclin D1 gene overexpression is closely associated with MCL. The PRAD1/cyclin D1 protein is localized to the nucleus, and the strong correlation between PRAD1/cyclin D1 and MCL is also found in the protein level. This finding indicates that PRAD1/cyclin D1 expression is a highly specific and sensitive molecular marker for MCL. This gene may function as an oncogene in the malignant transformation of cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cyclin D1
  • Cyclins / biosynthesis*
  • Cyclins / genetics*
  • Gene Expression
  • Humans
  • Lymphoma, Non-Hodgkin / genetics*
  • Lymphoma, Non-Hodgkin / metabolism*
  • Lymphoma, Non-Hodgkin / pathology
  • Oncogene Proteins / biosynthesis*
  • Oncogene Proteins / genetics*
  • Translocation, Genetic

Substances

  • Cyclins
  • Oncogene Proteins
  • Cyclin D1