One summer (heat stress) and one winter (neutral conditions) trial were conducted to assess the effects of varied amounts of RUP and fat on the growth and metabolic responses of calves. In each trial, 190-kg Holstein calves (n = 45) were fed a basal diet of corn and cottonseed hulls supplemented with soybean meal (control) or supplemented with raw or roasted whole soybeans or the basal ration plus prilled hydrogenated tallow either with or without a mixture of feather meal and blood meal. Prilled tallow was more detrimental to fiber digestion and growth performance than were whole soybeans, especially during summer. During winter, calves fed a high (49%) percentage of the dietary CP as RUP had similar BW gain and efficiency of feed usage as did calves fed a moderate percentage (39%), but, during summer, calves fed the high percentage of RUP had greater BW gain and efficiency than did calves fed moderate percentages of RUP. Ruminal concentrations of VFA were parallel to digestibilities of fiber in the total tract. Ruminal concentrations of ammonia or blood concentrations of urea were not consistent with the concentrations of RDP fed. Concentrations of glucose, NEFA, insulin, and thyroid hormones in the blood were primarily affected by season. Data suggested that a higher percentage and AA quality of RUP improved the growth of calves during summer but not during winter.