Proliferative potential and malignant transformation of ganglioglioma: immunohistochemical studies by MIB-1 and p53 staining

Noshuyo Byori. 1995;12(2):141-9.

Abstract

We studied two cases of ganglioglioma immunohistochemically by MIB-1 and p53 staining. The positive rate of MIB-1 in the ganglionic cells was 5.5% in Case 1 and 7.8% in Case 2, and that of MIB-1 in the gliomatous cells was 1.4 and 6.6% respectively. The labeling index of p53 in the ganglionic cells was 7.3% in Case 1 and 7.7% in Case 2, and that of the gliomatous cells was 1.9 and 3.4% respectively. MIB-1 and p53 did not stain ganglionic precursor cells. These results indicate that the ganglionic cells also take part in proliferation and have potential of malignant transformation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens, Nuclear
  • Biomarkers
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / metabolism*
  • Brain Neoplasms / pathology*
  • Cell Division
  • Cell Transformation, Neoplastic*
  • Child, Preschool
  • Female
  • Ganglioglioma / diagnostic imaging
  • Ganglioglioma / metabolism*
  • Ganglioglioma / pathology*
  • Humans
  • Immunohistochemistry / methods
  • Ki-67 Antigen
  • Magnetic Resonance Imaging
  • Nuclear Proteins / metabolism*
  • Staining and Labeling
  • Tomography, X-Ray Computed
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Antigens, Nuclear
  • Biomarkers
  • Ki-67 Antigen
  • Nuclear Proteins
  • Tumor Suppressor Protein p53