Abstract
We studied two cases of ganglioglioma immunohistochemically by MIB-1 and p53 staining. The positive rate of MIB-1 in the ganglionic cells was 5.5% in Case 1 and 7.8% in Case 2, and that of MIB-1 in the gliomatous cells was 1.4 and 6.6% respectively. The labeling index of p53 in the ganglionic cells was 7.3% in Case 1 and 7.7% in Case 2, and that of the gliomatous cells was 1.9 and 3.4% respectively. MIB-1 and p53 did not stain ganglionic precursor cells. These results indicate that the ganglionic cells also take part in proliferation and have potential of malignant transformation.
MeSH terms
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Aged
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Antigens, Nuclear
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Biomarkers
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Brain Neoplasms / diagnostic imaging
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Brain Neoplasms / metabolism*
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Brain Neoplasms / pathology*
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Cell Division
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Cell Transformation, Neoplastic*
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Child, Preschool
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Female
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Ganglioglioma / diagnostic imaging
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Ganglioglioma / metabolism*
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Ganglioglioma / pathology*
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Humans
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Immunohistochemistry / methods
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Ki-67 Antigen
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Magnetic Resonance Imaging
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Nuclear Proteins / metabolism*
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Staining and Labeling
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Tomography, X-Ray Computed
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Tumor Suppressor Protein p53 / metabolism*
Substances
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Antigens, Nuclear
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Biomarkers
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Ki-67 Antigen
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Nuclear Proteins
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Tumor Suppressor Protein p53