Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties

M Marinozzi; B Natalini; G Costantino; R Pellicciari; V Bruno; F Nicoletti

Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties

Farmaco. 1996 Feb;51(2):121-4.

Authors

M Marinozzi¹, B Natalini, G Costantino, R Pellicciari, V Bruno, F Nicoletti

Affiliation

¹ Instituto di Chimica e Tecnologia del Farmaco, Universita degli Studi di Perugia, Italy.

PMID: 8857207

Abstract

6,6-Dicarboxy-3,4-methano-L-proline (L-DCMP, 7) has been prepared by the rhodium(II)acetate dimer catalyzed decomposition of dimethyl diazomalonate in the presence of a 3,4-didehydroproline derivative. When evaluated against NMDA- and kainate-induced toxicity in cultured cortical neurons, L-DCMP (7) exhibited good neuroprotective activity.

MeSH terms

Animals
Cells, Cultured
Cerebral Cortex / drug effects
Female
Mice
Neuroprotective Agents / chemical synthesis*
Neuroprotective Agents / pharmacology
Pregnancy
Proline / analogs & derivatives*
Proline / chemical synthesis
Proline / pharmacology
Receptors, Glutamate / drug effects

Substances

6,6-dicarboxy-3,4-methano-L-proline
Neuroprotective Agents
Receptors, Glutamate
Proline