[Preventive effect of intracisternal methylprednisolone on symptomatic vasospasm after aneurysmal subarachnoid hemorrhage]

No Shinkei Geka. 1996 Feb;24(2):135-42.
[Article in Japanese]

Abstract

A series of 103 patients with ruptured cerebral aneurysms were treated by intracranial irrigation, after aneurysmal clipping, with pH 8.0 Hartmann solution containing 1 mg/ml of methylprednisolone sodium succinate, during operation. Postoperatively, 5 ml/day of the solution was also injected until day 14, percutaneously through an Ommaya reservoir into the cisterns around the clipped aneurysm. Six (5.7%) of the 103 patients suffered symptomatic vasospasm postoperatively. The Glasgow Outcome Scale at discharge of all patients indicated good recovery, Moderately disabled, Severely disabled and Vegetative state in 74 (72%), 18 (17%), 9 (9%) and 2 (2%) patients respectively. As a complication, subdural effusion was noticed in 17 (17%) patients, without any influence on outcome at all.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Female
  • Glasgow Coma Scale
  • Humans
  • Injections
  • Intracranial Aneurysm / complications*
  • Intracranial Aneurysm / surgery
  • Ischemic Attack, Transient / prevention & control*
  • Male
  • Methylprednisolone / administration & dosage*
  • Middle Aged
  • Subarachnoid Hemorrhage / complications*
  • Subarachnoid Hemorrhage / surgery

Substances

  • Methylprednisolone