Cytokeratin profiles and mucin secretion in combined hepatocellular-cholangiocarcinoma. A case report

Pathol Res Pract. 1996 May;192(5):488-91. doi: 10.1016/S0344-0338(96)80016-1.

Abstract

A case of a combined hepatocellular-cholangiocarcinoma (HCC-CC) is presented showing mucin production in both the HCC and the CC component. Immunohistochemical staining for cytokeratins 7 and 19 was performed and it is concluded that immunoreactivity for cytokeratin 7 and 19 is an additional criterion to the detection of mucin in making the diagnosis of a combined HCC-CC of the transitional type.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Hepatocellular / immunology*
  • Carcinoma, Hepatocellular / metabolism
  • Cell Differentiation / immunology
  • Cholangiocarcinoma / immunology*
  • Cholangiocarcinoma / metabolism
  • Female
  • Humans
  • Keratins / analysis*
  • Liver Neoplasms / immunology*
  • Liver Neoplasms / metabolism
  • Middle Aged
  • Mucins / analysis*
  • Mucins / metabolism*
  • Neoplasms, Multiple Primary / classification
  • Neoplasms, Multiple Primary / immunology*
  • Neoplasms, Multiple Primary / metabolism

Substances

  • Mucins
  • Keratins