[Evaluation of the stability of lipiodol-CDDP: suspension (LCS) by the pumping method]

Nihon Igaku Hoshasen Gakkai Zasshi. 1996 Aug;56(9):674-5.
[Article in Japanese]

Abstract

We purified cisplatin (CDDP) powder from CDDP solution and prepared a Lipiodol-CDDP-suspension (LCS) using the oily contrast medium Lipiodol in order to investigate its stability. Non-ionic contrast materials have surface activity. Iopamidol was chosen as a coupling agent. The compounding ratios of Lipiodol/Iopamidol 300/CDDP for stable suspension were 1 ml/1 ml/10 mg and 1 ml/1 ml/20 mg. These were also obtained easily by using the pumping method.

Publication types

  • English Abstract

MeSH terms

  • Antineoplastic Agents*
  • Cisplatin*
  • Contrast Media*
  • Drug Stability
  • Infusions, Intra-Arterial
  • Iodized Oil*
  • Iopamidol
  • Particle Size
  • Pressure*
  • Suspensions
  • Technology, Pharmaceutical

Substances

  • Antineoplastic Agents
  • Contrast Media
  • Suspensions
  • Iodized Oil
  • Iopamidol
  • Cisplatin