Pieces of the puzzle: assembling the preinitiation complex of Pol II

Structure. 1996 Aug 15;4(8):891-5. doi: 10.1016/s0969-2126(96)00096-2.

Abstract

Four new studies of the assembly of different subsets of the preinitiation complex of RNA polymerase II have provided insight into how transcription factors interact with each other and with DNA. A heterotetramer of TBP-associated factors shows a histone-like fold.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA / chemistry*
  • DNA / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • Histones / chemistry
  • Histones / metabolism
  • Humans
  • Macromolecular Substances
  • Models, Molecular
  • Nucleic Acid Conformation*
  • Nucleosomes / chemistry
  • Protein Binding
  • Protein Conformation*
  • RNA Polymerase II / chemistry*
  • RNA Polymerase II / metabolism
  • TATA Box
  • TATA-Box Binding Protein
  • Transcription Factor TFIIA
  • Transcription Factor TFIIB
  • Transcription Factor TFIID
  • Transcription Factors / chemistry*
  • Transcription Factors / metabolism
  • Transcription, Genetic*

Substances

  • DNA-Binding Proteins
  • Histones
  • Macromolecular Substances
  • Nucleosomes
  • TATA-Box Binding Protein
  • Transcription Factor TFIIA
  • Transcription Factor TFIIB
  • Transcription Factor TFIID
  • Transcription Factors
  • DNA
  • RNA Polymerase II