Abstract
Synaptic differentiation is triggered by signals from the ingrowing axon and is shaped by information exchange between the presynaptic and postsynaptic cells. The central role of agrin in this process, and the identity of the signaling component of its receptor, have now been established.
MeSH terms
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Agrin / metabolism
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Agrin / physiology
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Animals
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Cell Differentiation / physiology
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Enzyme Activation
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Muscles / enzymology
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Neuromuscular Junction / physiology*
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Phosphotransferases / metabolism
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RNA, Messenger / genetics
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Receptors, Cholinergic / genetics
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Signal Transduction
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Synapses / metabolism
Substances
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Agrin
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RNA, Messenger
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Receptors, Cholinergic
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Phosphotransferases