UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation, and biological properties

J Antibiot (Tokyo). 1996 Jul;49(7):639-43. doi: 10.7164/antibiotics.49.639.

Abstract

Novel antifungal antibiotics, UK-2A, B and a mixture of C and D, were obtained from the mycelial cake of Streptomyces sp. 517-02. All of the UK-2 compounds were similar in structure to antimycin A. The antifungal activities of UK-2 compounds were as strong as that of antimycin A. However, the UK-2 compounds demonstrated weak cytotoxicity compared to antimycin A.

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / pharmacology
  • Antifungal Agents / biosynthesis
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology*
  • Cell Division / drug effects
  • Fermentation
  • Glycine / analogs & derivatives*
  • Glycine / biosynthesis
  • Glycine / isolation & purification
  • Glycine / pharmacology
  • Humans
  • Lactones / chemical synthesis
  • Lactones / isolation & purification
  • Lactones / pharmacology
  • Mice
  • Microbial Sensitivity Tests
  • Oxygen Consumption / drug effects
  • Pyridines / chemical synthesis
  • Pyridines / isolation & purification
  • Pyridines / pharmacology
  • Saccharomyces cerevisiae / drug effects
  • Streptomyces / metabolism*
  • Tumor Cells, Cultured / drug effects
  • Uridine / analogs & derivatives*
  • Uridine / biosynthesis
  • Uridine / isolation & purification
  • Uridine / pharmacology

Substances

  • Antibiotics, Antineoplastic
  • Antifungal Agents
  • Lactones
  • Pyridines
  • UK 2A
  • UK 2B
  • UK 2C
  • UK 2D
  • UK 21
  • Glycine
  • Uridine