Propranolol 4- and 5-hydroxylation and N-desisopropylation by cloned human cytochrome P4501A1 and P4501A2

Drug Metab Dispos. 1996 Jun;24(6):692-4.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cytochrome P-450 CYP1A2 / chemistry
  • Cytochrome P-450 CYP1A2 / metabolism*
  • Cytochrome P-450 CYP2D6 / chemistry
  • Cytochrome P-450 CYP2D6 / metabolism*
  • Humans
  • Hydroxylation
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism*
  • Molecular Conformation
  • Propranolol / analogs & derivatives*
  • Propranolol / metabolism*

Substances

  • N-desisopropylpropranolol
  • 4-hydroxypropranolol
  • Propranolol
  • Cytochrome P-450 CYP1A2
  • Cytochrome P-450 CYP2D6