Globostellatic acids A-D, new cytotoxic isomalabaricane triterpenes from the marine sponge Stelletta globostellata

G Ryu; S Matsunaga; N Fusetani

doi:10.1021/np9601317

Globostellatic acids A-D, new cytotoxic isomalabaricane triterpenes from the marine sponge Stelletta globostellata

J Nat Prod. 1996 May;59(5):512-4. doi: 10.1021/np9601317.

Authors

G Ryu¹, S Matsunaga, N Fusetani

Affiliation

¹ Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan.

PMID: 8778241
DOI: 10.1021/np9601317

Abstract

Four new cytotoxic triterpenes, globostellatic acids A-D (1-4), have been isolated from the marine sponge Stelletta globostellata. Their structures have been determined by interpretation of spectral data. They exhibited cytotoxicity against P-388 murine leukemia cells with IC50 values of 0.1-0.46 microgram/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
Leukemia P388 / drug therapy
Magnetic Resonance Spectroscopy
Mice
Porifera / chemistry*
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Ultraviolet
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology

Substances

Antineoplastic Agents
Triterpenes