A new method of reproduction of myocardial ischemia and reperfusion is represented in this article. It permits studying: cardiodynamic changes accompanying the local myocardial ischemia and reperfusion under physiological conditions; changes in the retrograde blood flow from the ischemic region; changes in the reperfusion blood flow; intercoronary relations; biochemical parameters of the blood from the ischemic region of the myocardium.