Laboratory detection of antiphospholipid antibodies

Lupus. 1996 Apr;5(2):160-2. doi: 10.1177/096120339600500215.

Abstract

'Antiphospholipid' (aPL) antibodies are a heterogenous group of autoantibodies that are now considered to be directed mainly to plasma proteins or protein-phospholipid complexes. Standardisation of assays for anticardiolipin (aCL) antibodies and lupus anticoagulants (LA) have been fraught with difficulty despite numerous attempts to perform this by International Standardisation Workshops and Committees.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibodies, Anticardiolipin / analysis
  • Antibodies, Anticardiolipin / blood
  • Antibodies, Antiphospholipid / analysis
  • Antibodies, Antiphospholipid / blood*
  • Biomarkers / blood
  • Blood Coagulation Tests
  • Blood Proteins / immunology
  • Cattle
  • Diagnosis, Differential
  • Enzyme-Linked Immunosorbent Assay / methods
  • Enzyme-Linked Immunosorbent Assay / standards
  • Humans
  • Lupus Coagulation Inhibitor / analysis
  • Lupus Coagulation Inhibitor / blood
  • Lupus Erythematosus, Systemic / blood
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / immunology
  • Partial Thromboplastin Time
  • Phospholipids / immunology
  • Protein Binding

Substances

  • Antibodies, Anticardiolipin
  • Antibodies, Antiphospholipid
  • Biomarkers
  • Blood Proteins
  • Lupus Coagulation Inhibitor
  • Phospholipids