Comparison of the anti-inflammatory effect and gastrointestinal tolerability of aceclofenac and diclofenac

Arzneimittelforschung. 1996 Apr;46(4):398-400.

Abstract

Aceclofenac (CAS 89796-99-6) and diclofenac (CAS 15307-79-6) are orally effective non-steroidal anti-inflammatory drugs. Their anti-inflammatory and potential gastrointestinal damaging effects were compared following single and repeated administration (5 days). Both drugs exerted an anti-inflammatory activity and showed a similar gastrointestinal tolerability in the rat.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / toxicity*
  • Carrageenan
  • Diclofenac / analogs & derivatives*
  • Diclofenac / pharmacology
  • Diclofenac / toxicity
  • Edema / chemically induced
  • Edema / prevention & control
  • Male
  • Rats
  • Rats, Wistar
  • Stomach Ulcer / chemically induced*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Diclofenac
  • Carrageenan
  • aceclofenac