Nitric oxide induces cultured cortical neuron apoptosis

Neurosci Lett. 1996 Apr 12;208(1):1-4. doi: 10.1016/0304-3940(96)12532-5.

Abstract

A series of experiments were designed to examine the potential induction of apoptosis by nitric oxide (NO) donors on cortical neuronal cell culture. A 24 h exposure of three different NO donors, 3-morpholinosydnonimine, S-nitroso-N-acetyl-penicillamine, and S-nitrosoglutathione, induced apoptosis as indicated by following histological (cellular and nuclear morphology) and biochemical markers (DNA oligonucleosomal fragmentation and protection by protein synthesis inhibitor).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / drug effects*
  • Cells, Cultured
  • Cerebral Cortex / cytology*
  • Cerebral Cortex / drug effects
  • DNA / biosynthesis
  • Electrophoresis, Agar Gel
  • Glutathione / analogs & derivatives
  • Glutathione / pharmacology
  • Molsidomine / analogs & derivatives
  • Molsidomine / pharmacology
  • Nerve Tissue Proteins / biosynthesis
  • Neurons / drug effects*
  • Nitric Oxide / pharmacology*
  • Nitroso Compounds / pharmacology
  • Penicillamine / analogs & derivatives
  • Penicillamine / pharmacology
  • Rats
  • Rats, Wistar
  • S-Nitroso-N-Acetylpenicillamine
  • S-Nitrosoglutathione

Substances

  • Nerve Tissue Proteins
  • Nitroso Compounds
  • Nitric Oxide
  • S-Nitrosoglutathione
  • linsidomine
  • S-Nitroso-N-Acetylpenicillamine
  • DNA
  • Molsidomine
  • Glutathione
  • Penicillamine