Abstract
The synthesis of a variety of novel compounds structurally related to the antimicrobial natural product pyridazomycin via alkylation of appropriate azine and diazine derivatives is reported. Based on the results of preliminary antimicrobial tests the dependence of antimicrobial activity from several structural features of pyridazomycin is discussed.
MeSH terms
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Amino Acids / chemical synthesis*
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Amino Acids / pharmacology
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology
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Antifungal Agents / chemistry*
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Antifungal Agents / pharmacology*
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, High Pressure Liquid
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Pyridazines / chemistry
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Pyridazines / pharmacology
Substances
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Amino Acids
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Anti-Infective Agents
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Antifungal Agents
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Pyridazines
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pyridazomycin