Induction of SPI-3 mRNA, encoding a serine protease inhibitor, in gerbil hippocampus after transient forebrain ischemia

Brain Res Mol Brain Res. 1996 Jan;35(1-2):314-8. doi: 10.1016/0169-328x(95)00211-a.

Abstract

We cloned genes the expression of which is induced in the Mongolian gerbil (Meriones unguiculatus) hippocampus after transient forebrain ischemia by a differential display technique. Among these genes, a rat serine protease inhibitor SPI-3 homologue was isolated. Present analyses suggested that the expression of gerbil SPI-3 mRNA was closely associated with delayed neuronal death and may block activities of proteases leaking from degenerating neurons or may support neuronal survival.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Gerbillinae
  • Hippocampus / metabolism*
  • Hippocampus / pathology
  • Humans
  • In Situ Hybridization
  • Ischemic Attack, Transient / metabolism*
  • Ischemic Attack, Transient / pathology
  • Molecular Sequence Data
  • Neurons / metabolism
  • Neurons / pathology
  • RNA Probes
  • RNA, Messenger / biosynthesis
  • Rats
  • Sequence Homology, Amino Acid
  • Serine Proteinase Inhibitors / biosynthesis*
  • Time Factors
  • Transcription, Genetic*

Substances

  • RNA Probes
  • RNA, Messenger
  • Serine Proteinase Inhibitors