Deficient quantitative expression of CD45 isoforms on CD4+ and CD8+ T cell subpopulations and subsets of CD45RA(low)CD45RO(low) T cells in newborn blood

Biol Neonate. 1996;69(2):128-32. doi: 10.1159/000244287.

Abstract

Deficiencies in the quantitative expression of CD45RA and CD45RO on CD4+ and CD8+ T cells and in a population of CD45RA(low)CD45RO(low) T cells in blood from term newborn infants were found by flow cytometry. The relative frequencies of CD45RO on CD4+ T cells from adults and newborn infants were 72 and 58%, respectively. However, in newborn infants greater than 70% of T cells expressing CD45RO also expressed CD45RA. In addition, the quantitative expression of CD45RA and CD45RO on newborn T cells was significantly less than that found on adult blood T cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Fetal Blood / cytology
  • Flow Cytometry
  • Humans
  • Infant, Newborn
  • Leukocyte Common Antigens / biosynthesis*
  • Leukocyte Common Antigens / blood
  • Leukocyte Common Antigens / chemistry
  • T-Lymphocyte Subsets / immunology*

Substances

  • Leukocyte Common Antigens