Abstract
Bispecific antibodies can be used to redirect cytotoxic T cells to kill virus-infected cells, overriding the need for major histocompatibility complex restriction. We produced a bispecific antibody (3F12) which binds influenza virus M2 protein and the T-cell receptor and can redirect staphylococcal enterotoxin B-activated T cells to kill influenza virus-infected cells and inhibit virus replication in vitro.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Bispecific / immunology*
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Antibodies, Viral / immunology*
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Cell Line
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Dogs
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Enterotoxins / pharmacology
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Humans
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Influenza A virus / immunology*
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Influenza A virus / physiology
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Mice
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Mice, Inbred BALB C
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Molecular Sequence Data
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T-Lymphocytes, Cytotoxic / immunology*
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Viral Matrix Proteins / immunology*
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Virus Replication / immunology
Substances
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Antibodies, Bispecific
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Antibodies, Viral
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Enterotoxins
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M-protein, influenza virus
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M2 protein, Influenza A virus
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Viral Matrix Proteins
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enterotoxin B, staphylococcal