Intravenous immunoglobulin treatment of pregnant patients with unexplained recurrent abortions

Hum Reprod. 1996 Apr;11(4):711-5. doi: 10.1093/oxfordjournals.humrep.a019238.

Abstract

Intravenous immunoglobulins, first given to recurrent aborters with anti-phospholipid syndrome, have been administered to unexplained aborters since 1986. They probably have immunomodulatory properties beyond supplying blocking antibodies. When pregnancy was confirmed, women were started with a loading dose which was repeated every 3-4 weeks until the second trimester. Dosages were empirical. Pregnancy rates ranged between 50 and 82%. The main maternal complications, i.e. allergic reactions and infections, were rare.

Publication types

  • Review

MeSH terms

  • Abortion, Habitual / immunology
  • Abortion, Habitual / therapy*
  • Female
  • Humans
  • Immunoglobulins, Intravenous / administration & dosage*
  • Immunoglobulins, Intravenous / adverse effects
  • Pregnancy

Substances

  • Immunoglobulins, Intravenous