Persistence of cyclosporine after withdrawal of the drug in a patient with chronic liver transplant rejection. Role of the monoethylglycinexylidine test

Transplantation. 1996 Jun 15;61(11):1657-8. doi: 10.1097/00007890-199606150-00021.

Abstract

Patients with chronic rejection of liver allografts may show persistently high cyclosporine levels. This phenomenon may be due to a down-regulation of the P450 cytochrome system. The monoethylglycinexylidine test was useful in confirming this hypothesis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cyclosporine / pharmacokinetics*
  • Cytochrome P-450 Enzyme System / analysis
  • Female
  • Graft Rejection*
  • Humans
  • Immunosuppressive Agents / pharmacokinetics*
  • Liver Transplantation*

Substances

  • Immunosuppressive Agents
  • Cyclosporine
  • Cytochrome P-450 Enzyme System