Inhibition of mucosal lipid hyperoxidation by green tea extract in 1,2-dimethylhydrazine-induced rat colonic carcinogenesis

Cancer Lett. 1996 Jul 12;104(2):205-9. doi: 10.1016/0304-3835(96)04248-6.

Abstract

Phosphatidylcholine hydroperoxide (PCOOH) measured using a chemiluminescence detector to examine colonic mucosal lipid hyperoxidation increased after injection of 1,2-dimethylhydrazine and green tea extract (GTE), which we previously showed inhibited carcinogenesis and oxidative DNA damage in the gastrointestinal tract. Therefore, the hyperoxidation of membrane phospholipids reflected well the degree of DNA damage and carcinogenic alteration, and may be a useful intermediate biomarker for initiation of carcinogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1,2-Dimethylhydrazine
  • 8-Hydroxy-2'-Deoxyguanosine
  • Animals
  • Colonic Neoplasms / chemically induced
  • Colonic Neoplasms / metabolism*
  • Deoxyguanosine / analogs & derivatives
  • Deoxyguanosine / analysis
  • Dimethylhydrazines / toxicity
  • Lipid Peroxidation / drug effects*
  • Male
  • Phosphatidylcholines / analysis
  • Plant Extracts / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Tea*

Substances

  • Dimethylhydrazines
  • Phosphatidylcholines
  • Plant Extracts
  • Tea
  • phosphatidylcholine hydroperoxide
  • 8-Hydroxy-2'-Deoxyguanosine
  • Deoxyguanosine
  • 1,2-Dimethylhydrazine