Inhibitory effect of caloric restriction on tumorigenicity induced by 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) in the CD1 newborn mouse bioassay

Cancer Lett. 1996 Jul 12;104(2):133-6. doi: 10.1016/0304-3835(96)04232-2.

Abstract

The tumorigenicity of 4-aminobiphenyl (4-ABP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in combination with caloric restriction in the male neonatal CD1 mouse bioassay. 4-ABP and PhIP exhibited moderate and weak tumorigenicity, respectively, in ad libitum fed mice; however, none of the caloric restricted mice developed tumors. These results indicate that caloric restriction, even when begun 3 months after the conclusion of compound treatment, markedly inhibited 4-ABP- and PhIP-induced tumors in the CD1 mouse.

MeSH terms

  • Aminobiphenyl Compounds / toxicity*
  • Animals
  • Animals, Newborn
  • Carcinogens / toxicity*
  • Diet, Reducing
  • Energy Intake*
  • Imidazoles / toxicity*
  • Male
  • Mice
  • Neoplasms, Experimental / chemically induced
  • Neoplasms, Experimental / prevention & control*

Substances

  • Aminobiphenyl Compounds
  • Carcinogens
  • Imidazoles
  • 4-biphenylamine
  • 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine