7,12-dimethylbenz[a]anthracene-induced 'early' squamous cell carcinoma in the Golden Syrian hamster: evaluation of an animal model and comparison with 'early' forms of human squamous cell carcinoma in the upper aero-digestive tract

Int J Exp Pathol. 1996 Feb;77(1):7-14. doi: 10.1046/j.1365-2613.1996.956095.x.

Abstract

To test and optimize photodynamic therapy of early cancers in the upper aero-digestive tract and oesophagus, we sought an appropriate animal model, which was found in the 7,12-dimethylbenz[a]anthracene-induced early squamous cell carcinoma in the Golden Syrian hamster. This chemically induced neoplasm is shown, by histology and immunohistochemistry, to pass through similar stages of early cancer development as its human counterpart. Its time sequence is highly reproducible, leading to a well differentiated carcinoma in situ and microinvasive carcinoma in the hamster cheek pouch over a period of 10 weeks.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene / toxicity*
  • Animals
  • Carcinogens / toxicity*
  • Carcinoma in Situ / chemically induced
  • Carcinoma in Situ / pathology
  • Carcinoma, Squamous Cell / chemically induced*
  • Carcinoma, Squamous Cell / pathology
  • Cheek / pathology
  • Cricetinae
  • Disease Models, Animal*
  • Esophageal Neoplasms / chemically induced*
  • Keratins / metabolism
  • Male
  • Mesocricetus
  • Mouth Neoplasms / chemically induced
  • Mouth Neoplasms / pathology
  • Neoplasm Invasiveness
  • Photochemotherapy
  • Precancerous Conditions / chemically induced
  • Precancerous Conditions / pathology

Substances

  • Carcinogens
  • 9,10-Dimethyl-1,2-benzanthracene
  • Keratins