Increased risk of leukaemia in patients with juvenile chronic arthritis treated with chlorambucil

M J Kauppi; H A Savolainen; V J Anttila; H A Isomäki

doi:10.1111/j.1651-2227.1996.tb14004.x

Increased risk of leukaemia in patients with juvenile chronic arthritis treated with chlorambucil

Acta Paediatr. 1996 Feb;85(2):248-50. doi: 10.1111/j.1651-2227.1996.tb14004.x.

Authors

M J Kauppi¹, H A Savolainen, V J Anttila, H A Isomäki

Affiliation

¹ Rheumatism Foundation Hospital, Heinola, Finland.

PMID: 8640061
DOI: 10.1111/j.1651-2227.1996.tb14004.x

Abstract

Two cases of acute leukaemia have developed in a group of 77 patients treated with chlorambucil (Chl) because of severe juvenile chronic arthritis. The total follow-up from the beginning of Chl treatment in these patients was 560 years, indicating a highly increased risk of leukaemia. Despite favourable results, especially in patients with secondary amyloidosis, Chl should only be used in selected cases.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Alkylating / adverse effects*
Antineoplastic Agents, Alkylating / therapeutic use*
Arthritis, Juvenile / drug therapy*
Child, Preschool
Chlorambucil / adverse effects*
Chlorambucil / therapeutic use*
Female
Humans
Leukemia / chemically induced*
Male

Substances

Antineoplastic Agents, Alkylating
Chlorambucil