Human natural killer cell inhibitory receptors bind to HLA class I molecules

Eur J Immunol. 1996 Feb;26(2):365-9. doi: 10.1002/eji.1830260215.

Abstract

To obtain direct evidence that human natural killer cell (NK) inhibitory receptors physically interact with polymorphic determinants of major histocompatibility complex class I molecules, a receptor termed NK-associated transcript-2 has been produced as a soluble fusion protein with the human IgG1 Fc portion. This soluble receptor binds specifically to HLA-C alleles with serine 77 and asparagine 80 in cell adhesion assays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites / immunology
  • Cell Line
  • Cell Line, Transformed
  • Female
  • HLA-B Antigens / genetics
  • HLA-C Antigens / genetics
  • Histocompatibility Antigens Class I / genetics
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Killer Cells, Natural / chemistry
  • Killer Cells, Natural / metabolism*
  • Male
  • Mice
  • Molecular Sequence Data
  • Receptors, Immunologic / biosynthesis
  • Receptors, Immunologic / metabolism*
  • Receptors, KIR

Substances

  • HLA-B Antigens
  • HLA-C Antigens
  • Histocompatibility Antigens Class I
  • Receptors, Immunologic
  • Receptors, KIR