Localization of the human achaete-scute homolog gene (ASCL1) distal to phenylalanine hydroxylase (PAH) and proximal to tumor rejection antigen (TRA1) on chromosome 12q22-q23

Genomics. 1995 Nov 1;30(1):81-3. doi: 10.1006/geno.1995.0012.

Abstract

ASCL1, the human achaete-scute homolog, is a helix-loop-helix transcription factor that was previously assigned to chromosome 12 using a rodent-human somatic hybrid panel. We now placed this gene on a yeast artificial chromosome contig encompassing position 119 cM of the Généthon genetic map between the two genes phenylalanine hydroxylase (PAH) and tumor rejection antigen 1 (TRA1). We also localized ASCL1 in the 12q22-q23 cytogenetic interval by using fluorescence in situ hybridization.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens, Neoplasm / genetics*
  • Base Sequence
  • Basic Helix-Loop-Helix Transcription Factors
  • Chromosome Mapping*
  • Chromosomes, Artificial, Yeast / genetics
  • Chromosomes, Human, Pair 12*
  • DNA Primers / chemistry
  • DNA-Binding Proteins / genetics*
  • Genetic Markers
  • Humans
  • In Situ Hybridization, Fluorescence
  • Molecular Sequence Data
  • Phenylalanine Hydroxylase / genetics*
  • Transcription Factors / genetics*

Substances

  • ASCL1 protein, human
  • Antigens, Neoplasm
  • Basic Helix-Loop-Helix Transcription Factors
  • DNA Primers
  • DNA-Binding Proteins
  • Genetic Markers
  • Transcription Factors
  • Phenylalanine Hydroxylase