Abstract
In a randomized trial, a high dosage chloroquine monotherapy (45 mg/kg over 3 days) was compared with combination regimens of sulfadoxine/pyrimethamine and chloroquine/clindamycin for treating Gabonese school children with Plasmodium falciparum malaria. In chloroquine treated patients only 32% were ultimately cured. In contrast, more than 90% of patients were cured after treatment with either combination regimen.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / therapeutic use
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Antimalarials / administration & dosage
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Antimalarials / adverse effects
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Antimalarials / therapeutic use*
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Child
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Child, Preschool
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Chloroquine / administration & dosage
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Chloroquine / adverse effects
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Chloroquine / therapeutic use
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Clindamycin / administration & dosage
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Clindamycin / adverse effects
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Clindamycin / therapeutic use
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Drug Combinations
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Drug Resistance
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Female
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Gabon
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Humans
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Malaria, Falciparum / drug therapy*
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Male
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Parasitemia / drug therapy
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Plasmodium falciparum / drug effects
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Pyrimethamine / administration & dosage
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Pyrimethamine / adverse effects
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Pyrimethamine / therapeutic use
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Sulfadoxine / administration & dosage
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Sulfadoxine / adverse effects
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Sulfadoxine / therapeutic use
Substances
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Anti-Bacterial Agents
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Antimalarials
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Drug Combinations
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fanasil, pyrimethamine drug combination
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Clindamycin
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Sulfadoxine
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Chloroquine
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Pyrimethamine