Structuring cell-cycle biology

Structure. 1995 Nov 15;3(11):1131-4. doi: 10.1016/s0969-2126(01)00248-9.

Abstract

The recent determination of the crystal structures of both cyclin A and the cyclin a-CDK2 complex provides new insight into the cyclin- dependent activation of cyclin-dependent protein kinases.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • CDC2-CDC28 Kinases*
  • Cell Cycle / physiology*
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinases / chemistry*
  • Cyclin-Dependent Kinases / metabolism
  • Cyclins / chemistry*
  • Cyclins / metabolism
  • Eukaryotic Cells / cytology
  • Phosphorylation
  • Protein Binding
  • Protein Conformation*
  • Protein Processing, Post-Translational
  • Protein Serine-Threonine Kinases / chemistry*
  • Protein Serine-Threonine Kinases / metabolism
  • Structure-Activity Relationship

Substances

  • Cyclins
  • Protein Serine-Threonine Kinases
  • CDC2-CDC28 Kinases
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinases