The effect of temperature on the stability of the synthetic SPf(66)n malaria vaccine

M C López; M C Thomas; M Olivares; P Alonso; C Alonso

doi:10.1016/0264-410x(95)00054-5

The effect of temperature on the stability of the synthetic SPf(66)n malaria vaccine

Vaccine. 1995 Sep;13(13):1180-2. doi: 10.1016/0264-410x(95)00054-5.

Authors

M C López¹, M C Thomas, M Olivares, P Alonso, C Alonso

Affiliation

¹ Instituto de Parasitologia y Biomedicina López Neyra, CSIC, Granada, Spain.

PMID: 8578801
DOI: 10.1016/0264-410x(95)00054-5

Abstract

We hereby report on the effect of temperature on the physico-chemical and immunogenic characteristics and stability of the SPf(66)n synthetic malaria vaccine. The pattern of polymerization, the adsorption to aluminium hydroxide and the immunological properties of these vaccine groups were not significantly affected.

Publication types

Clinical Trial
Controlled Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Antigens, Protozoan*
Developing Countries
Drug Stability
Humans
Malaria Vaccines / chemistry*
Molecular Sequence Data
Plasmodium falciparum / immunology*
Public Health*
Temperature*
Vaccines, Synthetic / chemistry*

Substances

Antigens, Protozoan
Malaria Vaccines
Vaccines, Synthetic