8-Oxo-2'-deoxyguanosine level in lymphocytes DNA of cancer patients undergoing radiotherapy

Cancer Lett. 1996 Jan 19;99(1):93-7. doi: 10.1016/0304-3835(95)04042-0.

Abstract

We analyzed the level of 8-oxo-2'-deoxyguanosine in lymphocytes DNA of cancer patients undergoing radiotherapy. The results of this work indicate that exposure of cancer patients to therapeutic doses of ionizing radiation causes significant increase of the amount of 8-oxo-dG in DNA isolated from their lymphocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Chromatography, High Pressure Liquid
  • Colorectal Neoplasms / blood*
  • Colorectal Neoplasms / radiotherapy*
  • DNA, Neoplasm / blood*
  • DNA, Neoplasm / radiation effects*
  • Deoxyguanosine / analogs & derivatives*
  • Deoxyguanosine / blood
  • Dose-Response Relationship, Drug
  • Electrochemistry
  • Humans
  • Individuality
  • Lung Neoplasms / blood*
  • Lung Neoplasms / radiotherapy*
  • Lymphocytes / metabolism*
  • Lymphocytes / radiation effects*
  • Male
  • Middle Aged
  • Spectrophotometry, Ultraviolet

Substances

  • DNA, Neoplasm
  • 8-Hydroxy-2'-Deoxyguanosine
  • Deoxyguanosine