Abstract
A recombinant rat strain--Milan low-calpastatin strain (MLCS)--was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a model for studies of the calpain-calpastatin system, which is involved in important cellular mechanisms. Calpastatin polymorphism was observed in 10 different strains of laboratory rats and a single locus hypothesis is suggested as the mode of inheritance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood Pressure / genetics
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Blood Pressure / physiology
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Calcium-Binding Proteins / genetics
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Calcium-Binding Proteins / physiology*
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Calpain / physiology*
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Crosses, Genetic
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Cysteine Proteinase Inhibitors / genetics
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Cysteine Proteinase Inhibitors / physiology*
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Female
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Genotype
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Male
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Phenotype
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Polymorphism, Genetic
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Rats
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Rats, Inbred Strains / genetics*
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Recombination, Genetic
Substances
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Calcium-Binding Proteins
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Cysteine Proteinase Inhibitors
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calpastatin
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Calpain