Hydrocephalus, mineralizing angiopathy, hypercholesterolemia, and hyperlipoprotein (a)

Pediatr Neurol. 1995 Oct;13(3):257-60. doi: 10.1016/0887-8994(95)00158-c.

Abstract

A boy born at 34 weeks gestation with initially normal development presented with acute hydrocephalus at 22 months. Subsequently his development has been slow and complicated clinically by epilepsy. Upon extensive investigation, he has been found to have extremely elevated lipoprotein(a) levels, hypercholesterolemia (familial), and lesions of the cortex and meninges. Radiologic studies have disclosed a mineralizing angiopathy.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Biopsy
  • Brain / pathology
  • Calcinosis / complications*
  • Calcinosis / diagnostic imaging
  • Calcinosis / pathology
  • Cerebrospinal Fluid Proteins / analysis
  • Cerebrovascular Disorders / complications*
  • Cerebrovascular Disorders / diagnostic imaging
  • Cerebrovascular Disorders / pathology
  • Child
  • Cholesterol, LDL / blood
  • Female
  • Fibrosis
  • Humans
  • Hydrocephalus / complications*
  • Hydrocephalus / metabolism
  • Hydrocephalus / pathology
  • Hyperlipoproteinemia Type II / complications*
  • Hyperlipoproteinemia Type II / metabolism
  • Hyperlipoproteinemia Type II / pathology
  • Infant
  • Lipoprotein(a) / blood*
  • Male
  • Radiography

Substances

  • Cerebrospinal Fluid Proteins
  • Cholesterol, LDL
  • Lipoprotein(a)