Visual loss following treatment of sphenoid sinus carcinoma

Surv Ophthalmol. 1995 Jul-Aug;40(1):62-8. doi: 10.1016/s0039-6257(95)80048-4.

Abstract

A 71-year-old woman developed complete third nerve palsy and total blindness of the right eye one month after completing a course of radiotherapy for sphenoid sinus carcinoma over a 13-month period. Differential diagnosis included recurrence of the tumor, radiation-induced second neoplasm, empty sella with chiasmal prolapse and secondary chiasmal arachnoid adhesions, and radionecrosis. Magnetic resonance imaging demonstrated gadolinium contrast enhancement of the right intracranial optic nerve and chiasm, suggesting a radionecrosis process.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Blindness / etiology*
  • Carcinoma / etiology
  • Carcinoma / radiotherapy*
  • Chemotherapy, Adjuvant
  • Cisplatin / therapeutic use
  • Diagnosis, Differential
  • Female
  • Fluorouracil / therapeutic use
  • Humans
  • Magnetic Resonance Imaging
  • Neoplasms, Radiation-Induced / etiology
  • Neoplasms, Second Primary / etiology
  • Oculomotor Nerve Diseases / diagnosis
  • Oculomotor Nerve Diseases / etiology
  • Optic Atrophy / etiology
  • Optic Chiasm / pathology
  • Optic Chiasm / radiation effects*
  • Optic Nerve / pathology
  • Optic Nerve / radiation effects*
  • Paranasal Sinus Neoplasms / etiology
  • Paranasal Sinus Neoplasms / radiotherapy*
  • Radiation Injuries / etiology*
  • Sphenoid Sinus / radiation effects*
  • Visual Fields

Substances

  • Cisplatin
  • Fluorouracil