Omeprazole coinduces multiple xenobiotic-metabolizing enzymes in the rat

Ann N Y Acad Sci. 1995 Sep 30:768:237-42. doi: 10.1111/j.1749-6632.1995.tb12129.x.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Animals
  • Cytochrome P-450 Enzyme System / biosynthesis*
  • Cytosol / drug effects
  • Cytosol / enzymology
  • Duodenum / enzymology
  • Enzyme Induction
  • Enzyme Inhibitors / pharmacology*
  • Glucuronosyltransferase / biosynthesis*
  • Glutathione Transferase / biosynthesis*
  • Male
  • Microsomes / drug effects
  • Microsomes / enzymology*
  • Microsomes, Liver / enzymology*
  • Omeprazole / pharmacology*
  • Rats
  • Rats, Wistar
  • Xenobiotics / metabolism*

Substances

  • Enzyme Inhibitors
  • Xenobiotics
  • Cytochrome P-450 Enzyme System
  • Glucuronosyltransferase
  • Glutathione Transferase
  • Omeprazole